Cardiovascular Protocol • ICD-10 E78.5
Atherogenic Dyslipidemia & Elevated ApoB
Excess circulating apolipoprotein B-containing lipoproteins (LDL, VLDL remnants, Lp(a)) driving subendothelial arterial retention and atherosclerotic plaque progression.
Medically Reviewed by Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Atherogenic Dyslipidemia & Elevated ApoB Optimal Biomarker & Diagnostic Fact Matrix
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Classification | E78.5 | WHO / CMS ICD-10-CM Clinical Modification |
| Biomarker: Apolipoprotein B (ApoB) | < 60 mg/dL (high risk) / < 80 mg/dL | DotMD Preventive Optimal Target Range |
| Biomarker: Lipoprotein(a) | < 75 nmol/L (genetic baseline) | DotMD Preventive Optimal Target Range |
| Biomarker: hs-CRP | < 1.0 mg/L | DotMD Preventive Optimal Target Range |
| Biomarker: Non-HDL Cholesterol | < 90 mg/dL | DotMD Preventive Optimal Target Range |
Pathophysiology & Clinical Presentation
Reduced hepatic LDL-receptor recycling or excess hepatic VLDL assembly prolongs plasma residence of ApoB100 particles, enabling transcytosis across arterial endothelium, oxidative modification, and macrophage foam-cell formation.
Hallmark Clinical Signs & Biomarker Triggers
- Asymptomatic elevation of ApoB > 90 mg/dL or LDL-C > 100 mg/dL
- Coronary artery calcium (CAC) score > 0 Agatston units
- Tendon xanthomas or corneal arcus in familial hypercholesterolemia
Evidence-Based Medications & Cash Arbitrage for Atherogenic Dyslipidemia & Elevated ApoB
| Medication | Mechanism Class | Worth-It Score | Retail Avg | Lowest Cash |
|---|---|---|---|---|
| Ezetimibe Zetia | Intestinal NPC1L1 Sterol Transporter Inhibitor | 94.60% (36) | $98.00 | $6.60/mo |
| Pitavastatin Calcium Livalo, Zypitamag | Glycemic-Neutral Cyclopropyl HMG-CoA Reductase Inhibitor | 93.10% (23) | $284.00 | $14.20/mo |
| Rosuvastatin Calcium Crestor | Hydrophilic High-Potency HMG-CoA Reductase Inhibitor | 92.40% (44) | $86.00 | $5.70/mo |
| Low-Dose Colchicine (0.5–0.6 mg Vascular Anti-Inflammatory) Lodoco, Colcrys | Beta-Tubulin Polymerization & NLRP3 Inflammasome Inhibitor | 89.90% (22) | $118.00 | $9.20/mo |
| Atorvastatin Calcium Lipitor | Lipophilic HMG-CoA Reductase Inhibitor | 89.10% (37) | $72.00 | $5.40/mo |
| Icosapent Ethyl (Ultra-Pure EPA) Vascepa | Purified Ethyl Eicosapentaenoate Plaque Stabilizer | 86.00% (18) | $298.00 | $46.50/mo |
| Pravastatin Sodium Pravachol | Ultra-Hydrophilic Non-CYP Statin | 85.20% (15) | $44.00 | $6.10/mo |
| Bempedoic Acid Nexletol | Hepatocyte-Selective ATP Citrate Lyase (ACL) Inhibitor | 84.80% (14) | $448.00 | $129.00/mo |
| Fenofibrate Nanocrystal / Micronized Tricor, Fenoglide | PPAR-Alpha Nuclear Agonist & Lipoprotein Lipase Activator | 82.60% (13) | $68.00 | $8.90/mo |
INSTANT PRESCRIPTION & CASH ROUTING
DotMD Club Members get $29 flat-rate script renewals →
Verified Online Prescribers & Wholesale Pharmacies for Atherogenic Dyslipidemia & Elevated ApoB
Mark Cuban Cost Plus Drugs (Wholesale Pharmacy)
Requires an existing doctor prescription. Need a script? Pair with a $29 DotMD Club TeleMed consult.
$6.60/mo
Wholesale Cash Price
Sesame Direct Cash-Pay Prescriber Network (Online Doctor Consult + Delivery)
Asynchronous physician review included • Ships in ~1 days
$
29.00
Consult / Starting Tier