Brand Reference: Tricor, Fenoglide
| Metric | Verified Benchmark | Source |
|---|---|---|
| Fenofibrate Nanocrystal / Micronized RxNorm Concept ID | 876193 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.1650 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $68.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $8.90 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $11.00 / mo | 13 Zero-PHI Verified Patient Logs |
Hydrolyzed to fenofibric acid to activate hepatic PPAR-alpha transcription, upregulating lipoprotein lipase and ApoA-V while repressing ApoC-III—slashing fasting triglycerides by 35%–50% and shifting atherogenic small-dense LDL toward buoyant particles.
CMS National Average Drug Acquisition Cost (NADAC) tracking places Fenofibrate Nanocrystal / Micronized (Tricor / Fenoglide, RxCUI 876193) at $0.1650 per unit, whereas walk-in chain pharmacies bill cash patients an average of $68.00 monthly—creating a 87% ($59.10/mo) wholesale arbitrage spread down to $8.90.
Systemic exposure to Fenofibrate Nanocrystal / Micronized reflects ~81% nanocrystal formulation absorption kinetics and carboxylesterase hydrolysis and glucuronidation; 60% renal excretion, sustaining receptor engagement across a 20 hours half-life window (2 weeks triglyceride decline response profile).
Dosing protocols (48 mg PO once daily or 145 mg PO once daily) balance efficacy (82.60% patient satisfaction across 13 logs) against reversible serum creatinine +0.15 mg/dl (14% of reports), dyspepsia (6% of reports), with strict avoidance in egfr < 30 ml/min/1.73m2; pre-existing gallbladder cholelithiasis; primary biliary cholangitis.
Across 13 verified cash-pay logs, Fenofibrate Nanocrystal / Micronized achieves a 82.60% Worth-It rating with out-of-pocket spend averaging $11.00/mo versus $68.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 48 mg PO once daily for Fenofibrate Nanocrystal / Micronized; monthly out-of-pocket dropped to $7.83 compared with $68.00 retail.
Completed 10 weeks on Fenofibrate Nanocrystal / Micronized (145 mg PO once daily). Zero notable side effects on steady dosing.
Consistent biomarker response on 48 mg PO once daily Fenofibrate Nanocrystal / Micronized sourced via Cash Clinic ($10.32/mo cash pay without insurance prior authorization).