Brand Reference: Trintellix
| Metric | Verified Benchmark | Source |
|---|---|---|
| Vortioxetine Hydrobromide RxNorm Concept ID | 1455099 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $15.4000 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $518.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $99.00 / mo (Direct TeleMed) | Direct Telehealth Formulary |
| Community Mean Out-of-Pocket Paid | $125.00 / mo | 21 Zero-PHI Verified Patient Logs |
Combines SERT inhibition with full 5-HT1A agonism, 5-HT1B partial agonism, and potent 5-HT3/5-HT7/5-HT1D antagonism—disinhibiting hippocampal glutamate, acetylcholine, and histamine neurotransmission to improve processing speed (DSST cognitive tests) with low sexual dysfunction.
Out-of-pocket price dispersion on Vortioxetine Hydrobromide spans $125.00 to $518.00 per 30-day fill: pharmacy acquisition benchmarks sit near $15.4000/unit, allowing cash buyers bypassing PBM spread pricing to retain $393.00 each month (76% reduction).
With 66 hours (smooth natural self-taper) residence kinetics and 75% oral (food-independent) bioavailability, Vortioxetine Hydrobromide undergoes cyp2d6 (double check poor metabolizer max 10 mg) plus cyp3a4/2c9 and establishes therapeutic activity over 2–4 weeks cognitive clarity & mood response.
Standard adult regimens span 5 mg PO daily, 10 mg PO once daily, 20 mg PO once daily. Prescribers screen specifically against maoi within 14–21 days, while community micro-logs most frequently note dose-related transient nausea (take at bedtime) (29% of reports), pruritus (7% of reports).
Across 21 verified cash-pay logs, Vortioxetine Hydrobromide achieves a 86.20% Worth-It rating with out-of-pocket spend averaging $125.00/mo versus $518.00/mo walk-in retail.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Switched to TeleMed at 5 mg PO daily for Vortioxetine Hydrobromide; monthly out-of-pocket dropped to $110.00 compared with $518.00 retail.
Completed 10 weeks on Vortioxetine Hydrobromide (10 mg PO once daily). Zero notable side effects on steady dosing.
Consistent biomarker response on 20 mg PO once daily Vortioxetine Hydrobromide sourced via Cash Clinic ($145.00/mo cash pay without insurance prior authorization).