Fast-Tmax Lipophilic 5-HT1B / 5-HT1D Trigeminal Agonist • Rx

Rizatriptan Benzoate Orally Disintegrating (ODT)

Brand Reference: Maxalt, Maxalt-MLT

Medically Reviewed by Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
93.20%
Patient “Worth It”
31 verified logs
$7.60
Lowest Monthly Cash

Rizatriptan Benzoate Orally Disintegrating (ODT) Clinical & Real-World Cost Fact Matrix

Metric Verified Benchmark Source
Rizatriptan Benzoate Orally Disintegrating (ODT) RxNorm Concept ID 88014 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $0.3900 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $86.00 / mo CMS NADAC + U.S. Retail Markup Index
Mark Cuban Cost Plus Wholesale Price $7.60 / mo Cost Plus Drugs Wholesale Feed
Community Mean Out-of-Pocket Paid $9.80 / mo 31 Zero-PHI Verified Patient Logs
INSTANT PRESCRIPTION & CASH ROUTING

Verified Online Prescribers & Wholesale Pharmacies for Rizatriptan Benzoate Orally Disintegrating (ODT)

DotMD Club Members get $29 flat-rate script renewals →
Mark Cuban Cost Plus Drugs (Wholesale Pharmacy)
Requires an existing doctor prescription. Need a script? Pair with a $29 DotMD Club TeleMed consult.
$7.60/mo
Wholesale Cash Price
View Wholesale Rx →
AgelessRx Geroprotective Telehealth (Online Doctor Consult + Delivery)
Asynchronous physician review included • Ships in ~3 days • Rx included in monthly tier
$ 65.00
All-In Monthly
Start Online Visit →

Rizatriptan Benzoate Orally Disintegrating (ODT) Clinical Pharmacology & DailyMed Monograph

RxCUI 88014 • NDC 00378-3682-77

Engineered with 3x higher oral bioavailability and faster CNS/trigeminal Cmax than oral sumatriptan, suppressing dural calcitonin gene-related peptide (CGRP) extravasation for rapid 2-hour pain-free migraine termination.

For self-pay patients filling Rizatriptan Benzoate Orally Disintegrating (ODT) (NDC 00378-3682-77), direct wholesale and telehealth fulfillment drops monthly spend from $86.00 retail to $7.60 (91% savings against a $0.3900 CMS pharmacy acquisition baseline).

Clinical clearance of Rizatriptan Benzoate Orally Disintegrating (ODT) (Fast-Tmax Lipophilic 5-HT1B / 5-HT1D Trigeminal Agonist) relies on mao-a oxidative deamination (note: propranolol raises rizatriptan auc 70%—use 5 mg max with propranolol) with a 2–3 hours half-life; patients absorbing at 45% oral (3x oral sumatriptan) bioavailability typically observe target onset around 30–45 minutes.

FDA clinical labeling for Rizatriptan Benzoate Orally Disintegrating (ODT) restricts administration in ischemic heart disease or uncontrolled hypertension; hemiplegic migraine; maoi within 14 days across 5 mg ODT/PO at onset (mandatory cap if on propranolol), 10 mg ODT/PO at onset, with self-reported patient tracking dominated by neck heaviness (15% of reports), somnolence (14% of reports), dry mouth (9% of reports).

Half-Life
2–3 hours
Bioavailability
45% oral (3x oral sumatriptan)
Metabolism & Clearance
MAO-A oxidative deamination (NOTE: propranolol raises rizatriptan AUC 70%—use 5 mg max with propranolol)
Clinical Onset
30–45 minutes

Standard Adult Titration & Dosages

5 mg ODT/PO at onset (mandatory cap if on propranolol) 10 mg ODT/PO at onset

Absolute & Relative Contraindications

  • Ischemic heart disease or uncontrolled hypertension
  • Hemiplegic migraine
  • MAOI within 14 days

Logged Side-Effect Incidence (31 Reports)

Neck heaviness 15%
Somnolence 14%
Dry mouth 9%

Rizatriptan Benzoate Orally Disintegrating (ODT) Patient Dosage Logs & Out-of-Pocket Cost Ledger

Across 31 verified cash-pay logs, Rizatriptan Benzoate Orally Disintegrating (ODT) achieves a 93.20% Worth-It rating with out-of-pocket spend averaging $9.80/mo versus $86.00/mo walk-in retail.

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.

Effectiveness: 5/5 • Worth It Dosage: 5 mg ODT/PO at onset (mandatory cap if o • Paid: $6.69/mo via Cost Plus Drugs
Neck heaviness

Switched to Cost Plus Drugs at 5 mg ODT/PO at onset (mandatory cap if on propranolol) for Rizatriptan Benzoate Orally Disintegrating (ODT); monthly out-of-pocket dropped to $6.69 compared with $86.00 retail.

Effectiveness: 5/5 • Worth It Dosage: 10 mg ODT/PO at onset • Paid: $7.75/mo via TeleMed

Completed 10 weeks on Rizatriptan Benzoate Orally Disintegrating (ODT) (10 mg ODT/PO at onset). Zero notable side effects on steady dosing.

Effectiveness: 4/5 • Worth It Dosage: 5 mg ODT/PO at onset (mandatory cap if o • Paid: $8.82/mo via Compounding
Dry mouth

Consistent biomarker response on 5 mg ODT/PO at onset (mandatory cap if on propranolol) Rizatriptan Benzoate Orally Disintegrating (ODT) sourced via Compounding ($8.82/mo cash pay without insurance prior authorization).