Brand Reference: Inderal, Inderal LA
| Metric | Verified Benchmark | Source |
|---|---|---|
| Propranolol Hydrochloride RxNorm Concept ID | 8787 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0490 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $27.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $5.60 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $8.00 / mo | 41 Zero-PHI Verified Patient Logs |
Crosses the blood-brain barrier and antagonizes peripheral beta-1 and beta-2 adrenoceptors, abolishing epinephrine-driven somatic performance-anxiety tremor, vocal quaver, palpitations, and diaphoresis within 45 minutes without benzodiazepine cognitive sedation.
Across 41 community cost disclosures for Propranolol Hydrochloride (Inderal / Inderal LA), cash buyers routing around $27.00 retail markups capture a 79% discount ($5.60/mo benchmark vs $0.0490 NADAC acquisition).
Following administration (10 mg PO 45 min pre-event PRN), Propranolol Hydrochloride achieves ~26% oral (extensive hepatic first-pass) bioavailability and 30–60 minutes situational autonomic control onset, governed by a 3–6 hours IR terminal half-life through cyp2d6, cyp1a2, and cyp2c19 hydroxylation to 4-hydroxypropranolol.
Before initiating Propranolol Hydrochloride at 10 mg PO 45 min pre-event PRN, clinical safety checklists rule out reactive airway asthma or copd; raynaud phenomenon; sinus bradycardia < 50 bpm. Logged tolerability patterns center on cool extremities (11% of reports), mild tiredness (8% of reports).
Across 41 verified cash-pay logs, Propranolol Hydrochloride achieves a 93.50% Worth-It rating with out-of-pocket spend averaging $8.00/mo versus $27.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 10 mg PO 45 min pre-event PRN for Propranolol Hydrochloride; monthly out-of-pocket dropped to $4.93 compared with $27.00 retail.
Completed 10 weeks on Propranolol Hydrochloride (20 mg PO PRN or BID). Zero notable side effects on steady dosing.
Consistent biomarker response on 40 mg PO BID Propranolol Hydrochloride sourced via Cost Plus Drugs ($6.50/mo cash pay without insurance prior authorization).