Brand Reference: Xenical, Alli
| Metric | Verified Benchmark | Source |
|---|---|---|
| Orlistat RxNorm Concept ID | 37925 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $2.1500 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $195.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $59.00 / mo (Direct TeleMed) | Direct Telehealth Formulary |
| Community Mean Out-of-Pocket Paid | $68.00 / mo | 13 Zero-PHI Verified Patient Logs |
Forms a covalent ester bond with the active serine residue of gastric and pancreatic lipases inside the intestinal lumen, preventing hydrolysis of ~30% of ingested dietary triglycerides into absorbable free fatty acids and monoglycerides.
Across 13 community cost disclosures for Orlistat (Xenical / Alli), cash buyers routing around $195.00 retail markups capture a 65% discount ($68.00/mo benchmark vs $2.1500 NADAC acquisition).
Following administration (60 mg PO TID with fat-containing meals (OTC)), Orlistat achieves < 1% systemic absorption bioavailability and immediate intraluminal inhibition per fat-containing meal onset, governed by a 1–2 hours trace plasma / 24–48 hours fecal clearance terminal half-life through pre-systemic hydrolysis within gi wall to inactive m1 and m3 metabolites.
Before initiating Orlistat at 60 mg PO TID with fat-containing meals (OTC), clinical safety checklists rule out chronic malabsorption syndrome; cholestasis; pregnancy. Logged tolerability patterns center on steatorrhea (42% of reports), oily spotting (31% of reports), fat-soluble vitamin drop (12% of reports).
Across 13 verified cash-pay logs, Orlistat achieves a 64.50% Worth-It rating with out-of-pocket spend averaging $68.00/mo versus $195.00/mo walk-in retail.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Switched to Compounding at 60 mg PO TID with fat-containing meals (OTC) for Orlistat; monthly out-of-pocket dropped to $59.84 compared with $195.00 retail.
Completed 10 weeks on Orlistat (120 mg PO TID with meals (Rx)). Zero notable side effects on steady dosing.
Consistent biomarker response on 60 mg PO TID with fat-containing meals (OTC) Orlistat sourced via Cost Plus Drugs ($78.88/mo cash pay without insurance prior authorization).