Brand Reference: MetroGel, Noritate
| Metric | Verified Benchmark | Source |
|---|---|---|
| Metronidazole 0.75% / 1% Topical Gel RxNorm Concept ID | 6922 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.4600 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $114.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $15.80 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $18.00 / mo | 16 Zero-PHI Verified Patient Logs |
Quenches neutrophil-derived hydroxyl radicals and hydrogen peroxide inside perifollicular dermis, interrupting oxidative tissue injury and telangiectatic rosacea papules without systemic disulfiram reactions.
CMS National Average Drug Acquisition Cost (NADAC) tracking places Metronidazole 0.75% / 1% Topical Gel (MetroGel / Noritate, RxCUI 6922) at $0.4600 per unit, whereas walk-in chain pharmacies bill cash patients an average of $114.00 monthly—creating a 86% ($98.20/mo) wholesale arbitrage spread down to $15.80.
Systemic exposure to Metronidazole 0.75% / 1% Topical Gel reflects < 25 ng/mL serum (100x below single 250 mg oral tablet) absorption kinetics and negligible systemic nitro-reduction, sustaining receptor engagement across a Local dermal half-life ~10 hours half-life window (3–4 weeks baseline redness & papule reduction response profile).
Dosing protocols (0.75% gel BID or 1% gel once daily) balance efficacy (81.80% patient satisfaction across 16 logs) against slight stinging near eyes (11% of reports), dryness (9% of reports), with strict avoidance in nitroimidazole allergy.
Across 16 verified cash-pay logs, Metronidazole 0.75% / 1% Topical Gel achieves a 81.80% Worth-It rating with out-of-pocket spend averaging $18.00/mo versus $114.00/mo walk-in retail.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Switched to Cost Plus Drugs at 0.75% gel BID for Metronidazole 0.75% / 1% Topical Gel; monthly out-of-pocket dropped to $13.90 compared with $114.00 retail.
Completed 10 weeks on Metronidazole 0.75% / 1% Topical Gel (1% gel once daily). Zero notable side effects on steady dosing.
Consistent biomarker response on 0.75% gel BID Metronidazole 0.75% / 1% Topical Gel sourced via Compounding ($18.33/mo cash pay without insurance prior authorization).