Brand Reference: Cozaar
| Metric | Verified Benchmark | Source |
|---|---|---|
| Losartan Potassium RxNorm Concept ID | 52175 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0390 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $28.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $5.20 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $6.00 / mo | 26 Zero-PHI Verified Patient Logs |
Blocks AT1-mediated vasoconstriction and aldosterone secretion via parent losartan and its 10–40x more potent EXP3174 carboxylic acid metabolite, while uniquely inhibiting renal URAT1 urate reabsorption to lower serum uric acid.
Out-of-pocket price dispersion on Losartan Potassium spans $5.20 to $28.00 per 30-day fill: pharmacy acquisition benchmarks sit near $0.0390/unit, allowing cash buyers bypassing PBM spread pricing to retain $22.80 each month (81% reduction).
With 2 hours parent / 6–9 hours active EXP3174 metabolite residence kinetics and 33% oral bioavailability, Losartan Potassium undergoes cyp2c9 and cyp3a4 conversion (~14%) to active exp3174; dual renal/biliary clearance and establishes therapeutic activity over 6 hours peak bp drop; 3–6 weeks plateau.
Standard adult regimens span 25 mg PO daily, 50 mg PO daily (or 25 mg BID), 100 mg PO daily. Prescribers screen specifically against pregnancy; severe hepatic impairment without dose reduction, while community micro-logs most frequently note dizziness (8% of reports), nasal stuffiness (5% of reports).
Across 26 verified cash-pay logs, Losartan Potassium achieves a 87.50% Worth-It rating with out-of-pocket spend averaging $6.00/mo versus $28.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 25 mg PO daily for Losartan Potassium; monthly out-of-pocket dropped to $4.58 compared with $28.00 retail.
Completed 10 weeks on Losartan Potassium (50 mg PO daily (or 25 mg BID)). Zero notable side effects on steady dosing.
Consistent biomarker response on 100 mg PO daily Losartan Potassium sourced via Local Pharmacy ($6.03/mo cash pay without insurance prior authorization).