Brand Reference: Pregnyl, Novarel, Ovidrel
| Metric | Verified Benchmark | Source |
|---|---|---|
| Chorionic Gonadotropin (hCG / Pregnyl) RxNorm Concept ID | 5470 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $118.4000 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $278.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $115.00 / mo (Direct TeleMed) | Direct Telehealth Formulary |
| Community Mean Out-of-Pocket Paid | $128.00 / mo | 26 Zero-PHI Verified Patient Logs |
Heterodimeric glycoprotein sharing an identical alpha-subunit and 85% beta-subunit homology with pituitary LH that binds testicular Leydig-cell LHCGR receptors directly, maintaining intratesticular testosterone concentration and seminiferous spermatogenesis during exogenous TRT.
Out-of-pocket price dispersion on Chorionic Gonadotropin (hCG / Pregnyl) spans $128.00 to $278.00 per 30-day fill: pharmacy acquisition benchmarks sit near $118.4000/unit, allowing cash buyers bypassing PBM spread pricing to retain $150.00 each month (54% reduction).
With 29–36 hours biphasic residence kinetics and 35%–40% subcutaneous bioavailability, Chorionic Gonadotropin (hCG / Pregnyl) undergoes renal tubular degradation and glomerular excretion (~20% unchanged) and establishes therapeutic activity over 24–48 hours intratesticular steroidogenesis peak.
Standard adult regimens span 250 IU SC 3x weekly alongside TRT, 500 IU SC twice weekly, 1500 IU SC 3x weekly (fertility monotherapy). Prescribers screen specifically against androgen-dependent prostate carcinoma; precocious puberty; prior hcg anaphylaxis, while community micro-logs most frequently note intratesticular aromatase estradiol rise (22% of reports), nipple sensitivity (12% of reports), water retention (11% of reports).
Across 26 verified cash-pay logs, Chorionic Gonadotropin (hCG / Pregnyl) achieves a 91.00% Worth-It rating with out-of-pocket spend averaging $128.00/mo versus $278.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 250 IU SC 3x weekly alongside TRT for Chorionic Gonadotropin (hCG / Pregnyl); monthly out-of-pocket dropped to $112.64 compared with $278.00 retail.
Completed 10 weeks on Chorionic Gonadotropin (hCG / Pregnyl) (500 IU SC twice weekly). Zero notable side effects on steady dosing.
Consistent biomarker response on 1500 IU SC 3x weekly (fertility monotherapy) Chorionic Gonadotropin (hCG / Pregnyl) sourced via TeleMed ($148.48/mo cash pay without insurance prior authorization).