Brand Reference: Compounded GSH
| Metric | Verified Benchmark | Source |
|---|---|---|
| Reduced L-Glutathione (GSH Parenteral) RxNorm Concept ID | 4895 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $1.1200 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $165.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $95.00 / mo (Direct TeleMed) | Direct Telehealth Formulary |
| Community Mean Out-of-Pocket Paid | $99.00 / mo | 14 Zero-PHI Verified Patient Logs |
Gamma-glutamyl-cysteinyl-glycine tripeptide that donates reducing equivalents via glutathione peroxidase (GPx4) to neutralize lipid hydroperoxides, inhibits ferroptosis, regenerates oxidized ascorbate/tocopherol, and conjugates electrophilic xenobiotics via hepatic glutathione S-transferase.
Out-of-pocket price dispersion on Reduced L-Glutathione (GSH Parenteral) spans $99.00 to $165.00 per 30-day fill: pharmacy acquisition benchmarks sit near $1.1200/unit, allowing cash buyers bypassing PBM spread pricing to retain $66.00 each month (40% reduction).
With ~15–30 minutes plasma distribution; intracellular erythrocyte half-life ~4 days residence kinetics and ~95% intramuscular / subcutaneous (bypasses intestinal gamma-glutamyltransferase) bioavailability, Reduced L-Glutathione (GSH Parenteral) undergoes gamma-glutamyl cycle cleavage and renal cysteine/glycine reclamation and establishes therapeutic activity over 1–2 hours systemic redox shift.
Standard adult regimens span 100 mg IM/SC 2x weekly, 200 mg IM/SC 2–3x weekly. Prescribers screen specifically against sulfite-sensitive bronchospastic asthma; active cytotoxic chemotherapy requiring ros-mediated tumor kill, while community micro-logs most frequently note sulfur odor at injection site (16% of reports), local soreness (14% of reports).
Across 14 verified cash-pay logs, Reduced L-Glutathione (GSH Parenteral) achieves a 80.40% Worth-It rating with out-of-pocket spend averaging $99.00/mo versus $165.00/mo walk-in retail.
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Switched to TeleMed at 100 mg IM/SC 2x weekly for Reduced L-Glutathione (GSH Parenteral); monthly out-of-pocket dropped to $87.12 compared with $165.00 retail.
Completed 10 weeks on Reduced L-Glutathione (GSH Parenteral) (200 mg IM/SC 2–3x weekly). Zero notable side effects on steady dosing.
Consistent biomarker response on 100 mg IM/SC 2x weekly Reduced L-Glutathione (GSH Parenteral) sourced via Cash Clinic ($114.84/mo cash pay without insurance prior authorization).