Brand Reference: Cleocin-T
| Metric | Verified Benchmark | Source |
|---|---|---|
| Clindamycin Phosphate 1% Topical Gel / Lotion RxNorm Concept ID | 2582 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.3200 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $68.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $12.20 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $14.50 / mo | 18 Zero-PHI Verified Patient Logs |
Hydrolyzed on skin surfaces to active clindamycin, binding the 23S rRNA of the bacterial 50S ribosomal subunit in Cutibacterium acnes to halt peptidyl-transferase protein synthesis and cut free-fatty-acid neutrophil chemotaxis (always pair with benzoyl peroxide to prevent resistance).
CMS National Average Drug Acquisition Cost (NADAC) tracking places Clindamycin Phosphate 1% Topical Gel / Lotion (Cleocin-T, RxCUI 2582) at $0.3200 per unit, whereas walk-in chain pharmacies bill cash patients an average of $68.00 monthly—creating a 82% ($55.80/mo) wholesale arbitrage spread down to $12.20.
Systemic exposure to Clindamycin Phosphate 1% Topical Gel / Lotion reflects 1.7%–4% systemic absorption absorption kinetics and cutaneous phosphatase activation; minimal hepatic sulfoxidation, sustaining receptor engagement across a Local sebaceous follicle accumulation half-life window (2–6 weeks inflammatory pustule reduction response profile).
Dosing protocols (1% gel or lotion applied once or twice daily alongside benzoyl peroxide wash) balance efficacy (82.70% patient satisfaction across 18 logs) against local dryness (15% of reports), resistance rebound if used without bpo (12% of reports), with strict avoidance in history of ulcerative colitis, crohn enteritis, or c. difficile antibiotic-associated colitis.
Across 18 verified cash-pay logs, Clindamycin Phosphate 1% Topical Gel / Lotion achieves a 82.70% Worth-It rating with out-of-pocket spend averaging $14.50/mo versus $68.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 1% gel or lotion applied once or twice daily alongside benzoyl peroxide wash for Clindamycin Phosphate 1% Topical Gel / Lotion; monthly out-of-pocket dropped to $10.74 compared with $68.00 retail.
Completed 10 weeks on Clindamycin Phosphate 1% Topical Gel / Lotion (1% gel or lotion applied once or twice daily alongside benzoyl peroxide wash). Zero notable side effects on steady dosing.
Consistent biomarker response on 1% gel or lotion applied once or twice daily alongside benzoyl peroxide wash Clindamycin Phosphate 1% Topical Gel / Lotion sourced via Cost Plus Drugs ($14.15/mo cash pay without insurance prior authorization).