Effectiveness: 5/5 • Worth It
Dosage: 100 mg PO BID • Paid: $5.46/mo
via Cost Plus Drugs
Dyspepsia
Switched to Cost Plus Drugs at 100 mg PO BID for Celecoxib; monthly out-of-pocket dropped to $5.46 compared with $49.00 retail.
Diaryl-Substituted Pyrazole Selective Cyclooxygenase-2 (COX-2) Inhibitor • Rx
Celecoxib
Brand Reference: Celebrex
Medically Reviewed by Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
87.10%
Patient “Worth It”
28 verified logs
$6.20
Lowest Monthly Cash
Celecoxib Clinical & Real-World Cost Fact Matrix
| Metric | Verified Benchmark | Source |
|---|---|---|
| Celecoxib RxNorm Concept ID | 140587 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0680 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $49.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $6.20 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $7.80 / mo | 28 Zero-PHI Verified Patient Logs |
INSTANT PRESCRIPTION & CASH ROUTING
DotMD Club Members get $29 flat-rate script renewals →
Verified Online Prescribers & Wholesale Pharmacies for Celecoxib
Mark Cuban Cost Plus Drugs (Wholesale Pharmacy)
Requires an existing doctor prescription. Need a script? Pair with a $29 DotMD Club TeleMed consult.
$6.20/mo
Wholesale Cash Price
AgelessRx Geroprotective Telehealth (Online Doctor Consult + Delivery)
Asynchronous physician review included • Ships in ~3 days
• Rx included in monthly tier
$
65.00
All-In Monthly
Celecoxib Clinical Pharmacology & DailyMed Monograph
RxCUI 140587 • NDC 00378-5200-01
FDA Boxed Warning (Celecoxib):
NSAID class perioperative CABG contraindication, dose/duration cardiovascular thrombotic risk, and GI ulceration warning.
Inserts its sulfonamide side-pocket group into the larger hydrophobic channel of inducible inflammatory COX-2 (10-to-20-fold selectivity over gastric/platelet constitutive COX-1), suppressing prostaglandin E2 synovial inflammation while preserving gastric mucosal prostacyclin and TXA2 platelet aggregation.
Classified under Diaryl-Substituted Pyrazole Selective Cyclooxygenase-2 (COX-2) Inhibitor (Rx), Celecoxib exhibits a $42.80/month gap between standard U.S. retail cash counters ($49.00) and verified direct-to-patient routing ($6.20) anchored to $0.0680 CMS unit cost.
Pharmacokinetic profiling of Celecoxib demonstrates an elimination half-life of 11 hours with ~70% oral systemic bioavailability; clearance proceeds via hepatic cyp2c9 methyl-hydroxylation (halve dose in cyp2c9*3 poor metabolizers), reaching clinical onset within 60 minutes acute analgesia.
Titration schedules for Celecoxib (100 mg PO BID → 200 mg PO once daily) require excluding post-cabg surgery window; aspirin-exacerbated respiratory disease; sulfonamide anaphylaxis; real-world patient logs highlight dyspepsia (9% of reports), mild fluid retention (8% of reports) alongside a 87.10% Worth-It consensus.
Half-Life
11 hours
Bioavailability
~70% oral
Metabolism & Clearance
Hepatic CYP2C9 methyl-hydroxylation (halve dose in CYP2C9*3 poor metabolizers)
Clinical Onset
60 minutes acute analgesia
Standard Adult Titration & Dosages
100 mg PO BID 200 mg PO once daily
Absolute & Relative Contraindications
- Post-CABG surgery window
- Aspirin-exacerbated respiratory disease
- Sulfonamide anaphylaxis
Logged Side-Effect Incidence (28 Reports)
Dyspepsia 9%
Mild fluid retention 8%
Celecoxib Patient Dosage Logs & Out-of-Pocket Cost Ledger
Across 28 verified cash-pay logs, Celecoxib achieves a 87.10% Worth-It rating with out-of-pocket spend averaging $7.80/mo versus $49.00/mo walk-in retail.
15-Second Anonymous Micro-Log (Zero-PHI Architecture)
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Effectiveness: 5/5 • Worth It
Dosage: 200 mg PO once daily • Paid: $6.32/mo
via Cash Clinic
Completed 10 weeks on Celecoxib (200 mg PO once daily). Zero notable side effects on steady dosing.
Effectiveness: 4/5 • Worth It
Dosage: 100 mg PO BID • Paid: $7.19/mo
via Cost Plus Drugs
Dyspepsia
Consistent biomarker response on 100 mg PO BID Celecoxib sourced via Cost Plus Drugs ($7.19/mo cash pay without insurance prior authorization).