Brand Reference: Coreg
| Metric | Verified Benchmark | Source |
|---|---|---|
| Carvedilol RxNorm Concept ID | 20352 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0380 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $26.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $5.50 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $6.40 / mo | 16 Zero-PHI Verified Patient Logs |
Combines competitive beta-1 and beta-2 adrenoceptor blockade with peripheral vascular alpha-1 antagonism and carbazole-ring free-radical scavenging, lowering cardiac afterload while preserving insulin sensitivity compared with metoprolol.
Across 16 community cost disclosures for Carvedilol (Coreg), cash buyers routing around $26.00 retail markups capture a 79% discount ($5.50/mo benchmark vs $0.0380 NADAC acquisition).
Following administration (3.125 mg PO BID), Carvedilol achieves 25%–35% oral (take with food to slow absorption) bioavailability and 1–2 hours alpha-1 vasodilation onset, governed by a 7–10 hours terminal half-life through hepatic cyp2d6 and cyp2c9 ring oxidation plus biliary excretion.
Before initiating Carvedilol at 3.125 mg PO BID, clinical safety checklists rule out bronchospastic asthma; sick sinus syndrome; severe hepatic cirrhosis. Logged tolerability patterns center on postural dizziness without food (12% of reports), fatigue (9% of reports), bradycardia (8% of reports).
Across 16 verified cash-pay logs, Carvedilol achieves a 85.00% Worth-It rating with out-of-pocket spend averaging $6.40/mo versus $26.00/mo walk-in retail.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Switched to Cost Plus Drugs at 3.125 mg PO BID for Carvedilol; monthly out-of-pocket dropped to $4.84 compared with $26.00 retail.
Completed 10 weeks on Carvedilol (6.25 mg PO BID). Zero notable side effects on steady dosing.
Consistent biomarker response on 12.5 mg PO BID Carvedilol sourced via Compounding ($6.38/mo cash pay without insurance prior authorization).