Brand Reference: Differin Rx 0.3%
| Metric | Verified Benchmark | Source |
|---|---|---|
| Adapalene 0.3% Prescription Gel RxNorm Concept ID | 142407 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.8400 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $146.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $21.80 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $24.00 / mo | 26 Zero-PHI Verified Patient Logs |
Photostable rigid naphthoic-acid retinoid that selectively activates RAR-beta and RAR-gamma while sparing RAR-alpha and cytosolic CRABP-II, delivering potent pilosebaceous comedolysis and TLR-2 anti-inflammatory suppression with ~50% less erythema than tretinoin.
For self-pay patients filling Adapalene 0.3% Prescription Gel (NDC 00299-5910-45), direct wholesale and telehealth fulfillment drops monthly spend from $146.00 retail to $21.80 (85% savings against a $0.8400 CMS pharmacy acquisition baseline).
Clinical clearance of Adapalene 0.3% Prescription Gel (Third-Generation Naphthoic Acid Selective RAR-Beta/Gamma Retinoid) relies on o-demethylation and biliary excretion with a 7–51 hours trace dermal depot half-life; patients absorbing at < 0.25 ng/mL trace plasma (lipophilic follicular targeting) bioavailability typically observe target onset around 4–8 weeks microcomedone clearance.
FDA clinical labeling for Adapalene 0.3% Prescription Gel restricts administration in pregnancy; application over open abrasions or severe cheilitis across 0.1% gel nightly (OTC starter), 0.3% gel thin film nightly (Rx potency), with self-reported patient tracking dominated by mild scaling (22% of reports), transient stinging (14% of reports).
Across 26 verified cash-pay logs, Adapalene 0.3% Prescription Gel achieves a 89.60% Worth-It rating with out-of-pocket spend averaging $24.00/mo versus $146.00/mo walk-in retail.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Switched to Cost Plus Drugs at 0.1% gel nightly (OTC starter) for Adapalene 0.3% Prescription Gel; monthly out-of-pocket dropped to $19.18 compared with $146.00 retail.
Completed 10 weeks on Adapalene 0.3% Prescription Gel (0.3% gel thin film nightly (Rx potency)). Zero notable side effects on steady dosing.
Consistent biomarker response on 0.1% gel nightly (OTC starter) Adapalene 0.3% Prescription Gel sourced via TeleMed ($25.29/mo cash pay without insurance prior authorization).